Jessy Deshane, PhD

Assistant Professor of Medicine

Division of Pulmonary, Allergy & Critical Care Medicine
1530 3rd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294

 treena@uab.edu

Brief Bio

Jessy Deshane received her PhD in Biochemistry and Molecular Genetics from University of Alabama at Birmingham under the mentorship of Dr. Anupam Agarwal. After completing her post-doctoral training in Immunology with Dr. David Chaplin, in Department of Microbiology, she joined the faculty of the Division of Pulmonary Allergy and Critical Care Medicine in the Department of Medicine in 2011 as an Assistant Professor. 
 

Academic & Research Interests   Dr. Deshane is committed to an academic career combining basic and translational research with an emphasis on inflammatory diseases of the airway. The focus of Dr. Deshane's research program is to enhance our understanding of the role of myeloid-derived regulatory cells in chronic airway inflammatory diseases. Asthma is a chronic inflammatory disease of the airways in which innate and adaptive immune cells participate as drivers of the inflammatory response. Free radical species have long been implicated as critical mediators of the asthmatic inflammatory process.  Dr. Deshane's studies in a mouse model of allergic airway inflammation have established that subsets of free radical-producing myeloid-derived regulatory cells (MDRC) are master regulators of airway inflammation. They are potent modulators of both T cell responses and airway hyper-responsiveness.  Dr. Deshane has identified human MDRC with similar function in bronchoalveolar lavage of asthmatics. Her current research interests are (1) to explore the free radical and cytokine/chemokine mediated mechanisms underlying the differentiation and function of myeloid derived regulatory cells in the establishment of airway inflammation and resolution of inflammation (2) to investigate MDRC- mediated regulation of the balance of Tregulatory cells and Th17 cells which control the tolerance vs inflammation (3) to understand how environmental pollutants such as tobacco smoke would impact MDRC function and contribute to exacerbation of inflammation in asthmatic smokers. These studies will provide insight into the role of MDRC in tobacco related pathology of the lung.

Key Publications

1   J.T. Anderson, M. Zeng, Q. Li, R. Stapley, D.R. 2^nd. Moore, B. Chenna, N. Fineberg, J. Zmijewski, I.E. Eltoum, G.P. Siegal, A. Gaggar, S. Barnes, S.E. Velu, V.J. Thannickal, E. Abraham, R.P. Patel, J.R. Jr. Lancaster, D.D. Chaplin, M.T. Dransfield, J. S. Deshane.  Enhanced NO production and arginase activity are localized to the distal airways in asthmatic subjects. Free Radic Biol Med. 2011 Mar 15. (Epub ahead of print) PMID: 21419218.

2.   J. Deshane, J. Zmijewski, R. Luther, A. Gaggar, R. Deshane, J-F. Lai, X. Xu, M. Spell, K. Estell, C.T. Weaver, E. Abraham, L. Schwiebert & D.D. Chaplin. Free Radical Producing Myeloid-Derived Suppressor Cells : Potent activators and suppressors of Allergic Airway Inflammation. Mucosal Immunol. 2011 Apr 6. (Epub ahead of print) PMID 21471960.

3.   Deshane J & D.D. Chaplin. Follicular dendritic cell makes environmental sense. Immunity. 2010 Jul 23;33 (1):2-4.

4.   Deshane J, Kim J, Bolisetty S, Hock TD, Hill-Kapturczak N, Agarwal A. Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells. J Biol Chem. 2010 May 28;285 (22):16476-86.

5.  Kumar A, Deshane JS, Crossman DK, Bolisetty S, Yan BS, Kramnik I, Agarwal A, & Steyn AJ. Hemeoxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. J Biol Chem. 2008 Jun 27; 283 (26):18032-9. PMID: 18400743

6.   Dulak J, Deshane J, Jozkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation. 2008. Jan 15:117(2): 231-41. PMID: 18195184

7.    Deshane J, Chen S, Caballero S, Grochot-Przeczek A, Was H, Calzi SL,   Lach   R, Hock TD, Chen B, Hill-Kapturczak N, Siegal GP, Dulak J, Jozkowicz A, Grant MB, Agarwal A. Stromal cell-derived factor-1 promotes angiogenesis via a heme oxygenase-1 dependent mechanism. J Exp Med. 2007; 204(3):605-618. PMID: 17339405