Matalon, Sadis, Ph.D.

Clinical Subspecialty and Area(s) of Interest

• RSV Induced Injury to Vectorial Alveolar Na⁺ Transport
• Chlorine Injury to the Lung
• RONS and Ion Channels

Education and Degrees

• University of Minnesota, Minneapolis, Minnesota, M.S.,1973
• University of Minnesota, Minneapolis, Minnesota, Ph.D. ,1975

Awards and Honors

• Keynote speaker, International Scientific Conference on "New Frontiers in Biomedicine and Biotechnology", Danube University and IMC University of Applied Sciences, Krems, Austria

• Selected as the "Best Basic Science Professor" by the 2004 School of Medicine Class; recipient of the Caduceus award
• Deputy Editor, American Journal of Respiratory Cell and Molecular Biology
• Associate Editor, American Journal of Respiratory Cell and Molecular Biology
• Who's Who in ATS News
• Recognition Award for Scientific Accomplishment, American Thoracic Society
• Keynote speaker, 24th Annual Pan-Hellenic Medical Symposium, Athens, Greece
• Director, North Atlantic Treaty Organization Advanced Study Institute on Acute Lung Injury, Corfu, Greece
• Recipient, Argus Society Award for Instructional Excellence (Best Instructor, First Year Medical Class), University of Alabama at Birmingham
• Recipient, Joint Health Sciences Presidential Teaching Award for 1997, University of Alabama at Birmingham
• MERIT Award, National Institutes of Health
• Nominated for the Best Basic Science Teacher Award, School of Medicine, University of Alabama at Birmingham. Received award for Excellence in teaching (runner up to Best Instructor)

• Career Investigator Award, American Lung Association
• Fulbright Scholar, Macalester College

Professional Societies

• American Thoracic Society    

• The American Physiological Society

Recent Publications

• Chen L, Bosworth CA, Pico T, Collawn JF, Varga K, Gao Z, Clancy JP, Fontenberry JA, Lancaster Jr JR, Matalon S. Detanonoate and Nitrated Lipids Increase Chloride Secretion Across Lung Airway Cells. Am J Respir Cell Mol Biol. 2008 Feb 28;
• Varga K, Goldstein RF, Jurkuvenaite A, Chen L, Matalon S, Sorscher EJ, Bebok Z, Collawn JF.Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones. Biochem J. 2008 Mar 15;410(3):555-64.
• Davis IC, Matalon S. Epithelial sodium channels in the adult lung--important modulators of pulmonary health and disease.Adv Exp Med Biol. 2007;618:127-40.
• Song W, Matalon S. Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates. Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L855-8. Epub 2007 Aug 10. Review.
• Davis IC, Lazarowski ER, Chen FP, Hickman-Davis JM, Sullender WM, Matalon S. Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection. Am J Respir Cell Mol Biol. 2007 Oct;37(4):379-86. Epub 2007 May 31.
• Davis IC, Xu A, Gao Z, Hickman-Davis JM, Factor P, Sullender WM, Matalon S. Respiratory syncytial virus induces insensitivity to beta-adrenergic agonists in mouse lung epithelium in vivo. Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L281-9. Epub 2007 Apr 13.
• Factor P, Mutlu GM, Chen L, Mohameed J, Akhmedov AT, Meng FJ, Jilling T, Lewis ER, Johnson MD, Xu A, Kass D, Martino JM, Bellmeyer A, Albazi JS, Emala C, Lee HT, Dobbs LG, Matalon S. Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4083-8. Epub 2007 Feb 28.
• Su X, Li Q, Shrestha K, Cormet-Boyaka E, Chen L, Smith PR, Sorscher EJ, Benos DJ, Matalon S, Ji HL. Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2006 Dec 1;281(48):36960-8. Epub 2006 Sep 29.
• Hickman-Davis JM, Wang Z, Fierro-Perez GA, Chess PR, Page GP, Matalon S, Notter RH. Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection. Am J Respir Cell Mol Biol. 2007 Jan;36(1):103-13. Epub 2006 Aug 17.
• Kotamraju S, Matalon S, Matsunaga T, Shang T, Hickman-Davis JM, Kalyanaraman B. Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells. Free Radic Biol Med. 2006 Mar 15;40(6):1034-44. Epub 2005 Nov 17.
• Hall NG, Liu Y, Hickman-Davis JM, Davis GC, Myles C, Andrews EJ, Matalon S, Lang JD Jr. Bactericidal function of alveolar macrophages in mechanically ventilated rabbits. Am J Respir Cell Mol Biol. 2006 Jun;34(6):719-26. Epub 2006 Feb 10.
• Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S, Benos DJ. Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. J Biol Chem. 2006 Mar 24;281(12):8233-41. Epub 2006 Jan 19.
• Chen L, Patel RP, Teng X, Bosworth CA, Lancaster JR Jr, Matalon S. Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione. J Biol Chem. 2006 Apr 7;281(14):9190-9. Epub 2006 Jan 17.
• Davis IC, Lazarowski ER, Hickman-Davis JM, Fortenberry JA, Chen FP, Zhao X, Sorscher E, Graves LM, Sullender WM, Matalon S. Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus. Am J Respir Crit Care Med. 2006 Mar 15;173(6):673-82. Epub 2005 Dec 30.
• Hickman-Davis JM, McNicholas-Bevensee C, Davis IC, Ma HP, Davis GC, Bosworth CA, Matalon S. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care Med. 2006 Feb 1;173(3):334-44. Epub 2005 Oct 27.
• Matalon S, Rennard SI. Thrombin increases lung water by decreasing Na,K-ATPase activity.Am J Respir Cell Mol Biol. 2005 Oct;33(4):317-8.
• Eaton DC, Chen J, Ramosevac S, Matalon S, Jain L. Regulation of Na+ channels in lung alveolar type II epithelial cells. Proc Am Thorac Soc. 2004;1(1):10-6. Review.
• Matalon S, Ji HL. Oleic acid damages ion transport and promotes alveolar edema: the dark side of healthy living. Am J Respir Crit Care Med. 2005 Mar 1;171(5):424-5.
• Swystun V, Chen L, Factor P, Siroky B, Bell PD, Matalon S. Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+. Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L820-30. Epub 2004 Dec 30.
• Matalon S, Wright JR. Surfactant proteins and inflammation: the yin and the yang. Am J Respir Cell Mol Biol. 2004 Dec;31(6):585-6.
• Prince LS, Okoh VO, Moninger TO, Matalon S. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2004 Nov;287(5):L999-1006.
• Mutlu GM, Dumasius V, Burhop J, McShane PJ, Meng FJ, Welch L, Dumasius A, Mohebahmadi N, Thakuria G, Hardiman K, Matalon S, Hollenberg S, Factor P. Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ Res. 2004 Apr 30;94(8):1091-100. Epub 2004 Mar 11.
• Chen L, Fuller CM, Kleyman TR, Matalon S. Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species. Am J Physiol Renal Physiol. 2004 Jun;286(6):F1202-8. Epub 2004 Feb 17.